Cardiac remodelling hinders activation of cyclooxygenase-2, diminishing protection by delayed pharmacological preconditioning: role of HIF1a and CREB
نویسندگان
چکیده
Cardiovascular Anesthesia Research Laboratory, Center of Clinical Research, Institute of Anesthesiology, E-HOF, University Hospital Zurich, Rämistrasse 100, Zurich CH-8091, Switzerland; Center of Integrative Human Physiology, University of Zurich, Zurich, Switzerland; Institute of Laboratory Animal Sciences, University of Zurich, Zurich, Switzerland; Department of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland; and Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
منابع مشابه
Cardiac remodelling hinders activation of cyclooxygenase-2, diminishing protection by delayed pharmacological preconditioning: role of HIF1 alpha and CREB.
AIMS We tested whether delayed pharmacologic preconditioning elicited by isoflurane is protective in infarct-remodelled hearts. METHODS AND RESULTS Male Wistar rats were treated with the preconditioning drug isoflurane 6 weeks after permanent ligation of the left anterior descending coronary artery. Twenty-four and 48 h later, hearts were perfused on the Langendorff system and treated with cy...
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